![]() PK-PD analyses were conducted using Phoenix WinNonLin 6.3 (Pharsight). The PopPK model was used to determine GEP exposures associated with efficacy. coli ALL in kidney-infected immunocompetent (I+) and I- mice. coli ALL, 997577, ATCC25922, IR5 and NCTC13441 (MICs of 1 to 4 µg/mL) in thigh-infected neutropenic (I-) mice and against E. A population PK (PopPK) model was built in NONMEM using plasma exposures. ![]() Plasma and tissue samples (kidney or thigh homogenates) were collected at 15, 30, 60, 120, 240 and 360 minutes. Infected tissues were evaluated for bacterial burden at 24-h post-infection (baseline controls at 1-hour post-infection). The administered doses ranged from 1 to 200 mg/kg SC every 6 hours starting 1-hour post-infection. PK and PD studies were conducted in murine (male CD-1 mice) thigh and kidney infections.
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